Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles

• Main Authors: Hawkshaw N.J., Hardman J.A., Haslam I.S., Shahmalak A., Gilhar A., Lim X., Paus R.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: beta catenin; cyclosporine; dermatological agent; growth promotor; keratin; ligand; secreted frizzled related protein 1; unclassified drug; way 316606; Wnt protein; membrane protein; SFRP1 protein, human; signal peptide; Article; bioassay; concentration (parameters); confounding variable; controlled study; down regulation; ex vivo study; hair follicle; hair growth; hair loss; hair root; human; human tissue; immunofluorescence microscopy; in situ hybridization; male; microarray analysis; papillary dermis; pharmacological assay; protein expression; protein function; protein targeting; quantitative analysis; reverse transcription polymerase chain reaction; Wnt signaling; alopecia; antagonists and inhibitors; drug effect; organ culture technique; preclinical study; Alopecia; Cyclosporine; Drug Evaluation, Preclinical; Hair Follicle; Humans; Intercellular Signaling Peptides and Proteins; Male; Membrane Proteins; Organ Culture Techniques; Wnt Signaling Pathway
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161883
• Institution: National University of Singapore

10.1371/journal.pbio.2003705