Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles

10.1371/journal.pbio.2003705

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Main Authors:	Hawkshaw N.J., Hardman J.A., Haslam I.S., Shahmalak A., Gilhar A., Lim X., Paus R.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2019
Subjects:	beta catenin cyclosporine dermatological agent growth promotor keratin ligand secreted frizzled related protein 1 unclassified drug way 316606 Wnt protein membrane protein SFRP1 protein, human signal peptide Article bioassay concentration (parameters) confounding variable controlled study down regulation ex vivo study hair follicle hair growth hair loss hair root human human tissue immunofluorescence microscopy in situ hybridization male microarray analysis papillary dermis pharmacological assay protein expression protein function protein targeting quantitative analysis reverse transcription polymerase chain reaction Wnt signaling alopecia antagonists and inhibitors drug effect organ culture technique preclinical study Alopecia Cyclosporine Drug Evaluation, Preclinical Hair Follicle Humans Intercellular Signaling Peptides and Proteins Male Membrane Proteins Organ Culture Techniques Wnt Signaling Pathway
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161883
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-161883
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spelling	sg-nus-scholar.10635-1618832024-11-11T18:55:54Z Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles Hawkshaw N.J. Hardman J.A. Haslam I.S. Shahmalak A. Gilhar A. Lim X. Paus R. DUKE-NUS MEDICAL SCHOOL beta catenin cyclosporine dermatological agent growth promotor keratin ligand secreted frizzled related protein 1 unclassified drug way 316606 Wnt protein cyclosporine membrane protein SFRP1 protein, human signal peptide Article bioassay concentration (parameters) confounding variable controlled study down regulation ex vivo study hair follicle hair growth hair loss hair root human human tissue immunofluorescence microscopy in situ hybridization male microarray analysis papillary dermis pharmacological assay protein expression protein function protein targeting quantitative analysis reverse transcription polymerase chain reaction Wnt signaling alopecia antagonists and inhibitors drug effect hair follicle organ culture technique preclinical study Alopecia Cyclosporine Drug Evaluation, Preclinical Hair Follicle Humans Intercellular Signaling Peptides and Proteins Male Membrane Proteins Organ Culture Techniques Wnt Signaling Pathway 10.1371/journal.pbio.2003705 PLoS Biology 16 5 e2003705 2019-11-08T06:42:17Z 2019-11-08T06:42:17Z 2018 Article Hawkshaw N.J., Hardman J.A., Haslam I.S., Shahmalak A., Gilhar A., Lim X., Paus R. (2018). Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles. PLoS Biology 16 (5) : e2003705. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pbio.2003705 15449173 https://scholarbank.nus.edu.sg/handle/10635/161883 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	beta catenin cyclosporine dermatological agent growth promotor keratin ligand secreted frizzled related protein 1 unclassified drug way 316606 Wnt protein cyclosporine membrane protein SFRP1 protein, human signal peptide Article bioassay concentration (parameters) confounding variable controlled study down regulation ex vivo study hair follicle hair growth hair loss hair root human human tissue immunofluorescence microscopy in situ hybridization male microarray analysis papillary dermis pharmacological assay protein expression protein function protein targeting quantitative analysis reverse transcription polymerase chain reaction Wnt signaling alopecia antagonists and inhibitors drug effect hair follicle organ culture technique preclinical study Alopecia Cyclosporine Drug Evaluation, Preclinical Hair Follicle Humans Intercellular Signaling Peptides and Proteins Male Membrane Proteins Organ Culture Techniques Wnt Signaling Pathway
spellingShingle	beta catenin cyclosporine dermatological agent growth promotor keratin ligand secreted frizzled related protein 1 unclassified drug way 316606 Wnt protein cyclosporine membrane protein SFRP1 protein, human signal peptide Article bioassay concentration (parameters) confounding variable controlled study down regulation ex vivo study hair follicle hair growth hair loss hair root human human tissue immunofluorescence microscopy in situ hybridization male microarray analysis papillary dermis pharmacological assay protein expression protein function protein targeting quantitative analysis reverse transcription polymerase chain reaction Wnt signaling alopecia antagonists and inhibitors drug effect hair follicle organ culture technique preclinical study Alopecia Cyclosporine Drug Evaluation, Preclinical Hair Follicle Humans Intercellular Signaling Peptides and Proteins Male Membrane Proteins Organ Culture Techniques Wnt Signaling Pathway Hawkshaw N.J. Hardman J.A. Haslam I.S. Shahmalak A. Gilhar A. Lim X. Paus R. Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles
description	10.1371/journal.pbio.2003705
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Hawkshaw N.J. Hardman J.A. Haslam I.S. Shahmalak A. Gilhar A. Lim X. Paus R.
format	Article
author	Hawkshaw N.J. Hardman J.A. Haslam I.S. Shahmalak A. Gilhar A. Lim X. Paus R.
author_sort	Hawkshaw N.J.
title	Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles
title_short	Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles
title_full	Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles
title_fullStr	Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles
title_full_unstemmed	Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles
title_sort	identifying novel strategies for treating human hair loss disorders: cyclosporine a suppresses the wnt inhibitor, sfrp1, in the dermal papilla of human scalp hair follicles
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161883
_version_	1821212759925194752

Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles

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