Hybrid-drug design targeting pseudomonas aeruginosa DHPS and DHFR

Hybrid-drug design targeting pseudomonas aeruginosa DHPS and DHFR

In this study, we successfully present the dual-target design hypothesis to inhibit both dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) enzymes using a novel scheme that integrates our previous antibiotic-phytochemical interaction data, fragment combination and knowledge-based me...

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Bibliographic Details
Main Authors: Jayaraman, Premkumar, Daniel, Lim Chu Siang, Siddiqi, Mohammad Imran, Dhillon, Sarinder Kaur, Sakharkar, Kishore R., Sakharkar, Meena K.
Other Authors: BioMedical Engineering Research Centre
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/84863
http://hdl.handle.net/10220/24068
https://www.bioscience.org/2013/v5e/af/666/fulltext.htm
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/84863
http://hdl.handle.net/10220/24068
https://www.bioscience.org/2013/v5e/af/666/fulltext.htm

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