Hybrid-drug design targeting pseudomonas aeruginosa DHPS and DHFR

• Main Authors: Jayaraman, Premkumar, Daniel, Lim Chu Siang, Siddiqi, Mohammad Imran, Dhillon, Sarinder Kaur, Sakharkar, Kishore R., Sakharkar, Meena K.
• Other Authors: BioMedical Engineering Research Centre
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/84863; http://hdl.handle.net/10220/24068; https://www.bioscience.org/2013/v5e/af/666/fulltext.htm
• Institution: Nanyang Technological University

In this study, we successfully present the dual-target design hypothesis to inhibit both dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) enzymes using a novel scheme that integrates our previous antibiotic-phytochemical interaction data, fragment combination and knowledge-based me...