Hybrid-drug design targeting pseudomonas aeruginosa DHPS and DHFR
In this study, we successfully present the dual-target design hypothesis to inhibit both dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) enzymes using a novel scheme that integrates our previous antibiotic-phytochemical interaction data, fragment combination and knowledge-based me...
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| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/84863 http://hdl.handle.net/10220/24068 https://www.bioscience.org/2013/v5e/af/666/fulltext.htm |
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| Institution: | Nanyang Technological University |
| Language: | English |