Design of planar microcoil-based NMR probe ensuring high SNR

A microNMR probe for ex vivo applications may consist of at least one microcoil, which can be used as the oscillating magnetic field (MF) generator as well as receiver coil, and a sample holder, with a volume in the range of nanoliters to micro-liters, placed near the microcoil. The Signal-to-Noise...

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Main Authors: Ali, Zishan, Aditya, Sheel, Poenar, Daniel Puiu
Other Authors: School of Electrical and Electronic Engineering
Format: Article
Language:English
Published: 2019
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Online Access:https://hdl.handle.net/10356/85411
http://hdl.handle.net/10220/48214
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-854112020-03-07T13:57:27Z Design of planar microcoil-based NMR probe ensuring high SNR Ali, Zishan Aditya, Sheel Poenar, Daniel Puiu School of Electrical and Electronic Engineering Centre of Excellence for Micro and Nanoelectronics Magnetic Energy Semiconductors DRNTU::Engineering::Electrical and electronic engineering A microNMR probe for ex vivo applications may consist of at least one microcoil, which can be used as the oscillating magnetic field (MF) generator as well as receiver coil, and a sample holder, with a volume in the range of nanoliters to micro-liters, placed near the microcoil. The Signal-to-Noise ratio (SNR) of such a probe is, however, dependent not only on its design but also on the measurement setup, and the measured sample. This paper introduces a performance factor P independent of both the proton spin density in the sample and the external DC magnetic field, and which can thus assess the performance of the probe alone. First, two of the components of the P factor (inhomogeneity factor K and filling factor η) are defined and an approach to calculate their values for different probe variants from electromagnetic simulations is devised. A criterion based on dominant component of the magnetic field is then formulated to help designers optimize the sample volume which also affects the performance of the probe, in order to obtain the best SNR for a given planar microcoil. Finally, the P factor values are compared between different planar microcoils with different number of turns and conductor aspect ratios, and planar microcoils are also compared with conventional solenoids. These comparisons highlight which microcoil geometry-sample volume combination will ensure a high SNR under any external setup. Published version 2019-05-16T01:37:24Z 2019-12-06T16:03:17Z 2019-05-16T01:37:24Z 2019-12-06T16:03:17Z 2017 Journal Article Ali, Z., Poenar, D. P., & Aditya, S. (2017). Design of planar microcoil-based NMR probe ensuring high SNR. AIP Advances, 7(9), 095107-. doi:10.1063/1.5002721 https://hdl.handle.net/10356/85411 http://hdl.handle.net/10220/48214 10.1063/1.5002721 en AIP Advances © 2017 The Author(s). All rights reserved. This paper was published by American Institute of Physics in AIP Advances and is made available with permission of The Author(s). 15 p. application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Magnetic Energy
Semiconductors
DRNTU::Engineering::Electrical and electronic engineering
spellingShingle Magnetic Energy
Semiconductors
DRNTU::Engineering::Electrical and electronic engineering
Ali, Zishan
Aditya, Sheel
Poenar, Daniel Puiu
Design of planar microcoil-based NMR probe ensuring high SNR
description A microNMR probe for ex vivo applications may consist of at least one microcoil, which can be used as the oscillating magnetic field (MF) generator as well as receiver coil, and a sample holder, with a volume in the range of nanoliters to micro-liters, placed near the microcoil. The Signal-to-Noise ratio (SNR) of such a probe is, however, dependent not only on its design but also on the measurement setup, and the measured sample. This paper introduces a performance factor P independent of both the proton spin density in the sample and the external DC magnetic field, and which can thus assess the performance of the probe alone. First, two of the components of the P factor (inhomogeneity factor K and filling factor η) are defined and an approach to calculate their values for different probe variants from electromagnetic simulations is devised. A criterion based on dominant component of the magnetic field is then formulated to help designers optimize the sample volume which also affects the performance of the probe, in order to obtain the best SNR for a given planar microcoil. Finally, the P factor values are compared between different planar microcoils with different number of turns and conductor aspect ratios, and planar microcoils are also compared with conventional solenoids. These comparisons highlight which microcoil geometry-sample volume combination will ensure a high SNR under any external setup.
author2 School of Electrical and Electronic Engineering
author_facet School of Electrical and Electronic Engineering
Ali, Zishan
Aditya, Sheel
Poenar, Daniel Puiu
format Article
author Ali, Zishan
Aditya, Sheel
Poenar, Daniel Puiu
author_sort Ali, Zishan
title Design of planar microcoil-based NMR probe ensuring high SNR
title_short Design of planar microcoil-based NMR probe ensuring high SNR
title_full Design of planar microcoil-based NMR probe ensuring high SNR
title_fullStr Design of planar microcoil-based NMR probe ensuring high SNR
title_full_unstemmed Design of planar microcoil-based NMR probe ensuring high SNR
title_sort design of planar microcoil-based nmr probe ensuring high snr
publishDate 2019
url https://hdl.handle.net/10356/85411
http://hdl.handle.net/10220/48214
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