Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols

• Main Authors: Huang, Zhijian, Huang, Xuan, Li, Baosheng, Mou, Chengli, Yang, Song, Song, Bao-An, Chi, Yonggui Robin
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Bisphenols; Phosphinates
• Online Access: https://hdl.handle.net/10356/85621; http://hdl.handle.net/10220/43779
• Institution: Nanyang Technological University

A carbene-catalyzed desymmetrization of prochiral bisphenol compounds bearing remote P-stereogenic centers is disclosed. The catalytic reactions can be performed on gram scales with 1 mol % N-heterocyclic carbene (NHC) catalyst, providing efficient access to enantiomerically enriched P-stereogenic p...