Porcine hepatocytes culture on biofunctionalized 3D inverted colloidal crystal scaffolds as an in vitro model for predicting drug hepatotoxicity

• Main Authors: Wu, Lingyan, Ferracci, Gaia, Wang, Yan, Fan, Teng Fei, Cho, Nam-Joon, Chow, Pierce K. H.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Drug-induced Hepatotoxicity; Engineering::Materials; Cell Culture
• Online Access: https://hdl.handle.net/10356/85716; http://hdl.handle.net/10220/49833
• Institution: Nanyang Technological University

As drug-induced hepatotoxicity represents one of the most common causes of drug failure, three-dimensional (3D) in vitro liver platforms represent a fantastic toolbox to predict drug toxicity and thus reduce in vivo animal studies and lessen drug attrition rates. The aim of this study is to establis...