NME proteins regulate class switch recombination

• Main Authors: Zheng, Simin, Kusnadi, Anthony, Choi, Jee Eun, Vuong, Bao Q., Rhodes, Daniela, Chaudhuri, Jayanta
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: DNA Recombination; G‐quadruplex; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/86130; http://hdl.handle.net/10220/49849
• Institution: Nanyang Technological University

Class switch recombination (CSR) in B cells involves deletion‐recombination at switch (S) region DNA and is important for the diversification of antibody isotypes during an immune response. Here, we identify two NME [NM23/NDPK (nucleoside diphosphate kinase)] isoforms, NME1 and NME2, as novel player...