Palladium-catalyzed para-selective alkylation of electron-deficient arenes

Palladium-catalyzed para-selective alkylation of electron-deficient arenes

Intermolecular alkylations of electron‐deficient arenes proceed with good para selectivity. Palladium catalysts were used to generate nucleophilic alkyl radicals from alkyl halides, which then directly add onto the arenes. The arene scope and the site of alkylation are opposite to those of classical...

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Main Authors: Jiao, Zhiwei, Lim, Li Hui, Hirao, Hajime, Zhou, Steve Jianrong
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2019
Subjects:
DRNTU::Science::Chemistry
Alkyl Radicals
Alkylation
Online Access:https://hdl.handle.net/10356/86198
http://hdl.handle.net/10220/48297
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-861982023-02-28T19:31:43Z Palladium-catalyzed para-selective alkylation of electron-deficient arenes Jiao, Zhiwei Lim, Li Hui Hirao, Hajime Zhou, Steve Jianrong School of Physical and Mathematical Sciences DRNTU::Science::Chemistry Alkyl Radicals Alkylation Intermolecular alkylations of electron‐deficient arenes proceed with good para selectivity. Palladium catalysts were used to generate nucleophilic alkyl radicals from alkyl halides, which then directly add onto the arenes. The arene scope and the site of alkylation are opposite to those of classical Friedel–Crafts alkylations, which prefer electron‐rich systems. MOE (Min. of Education, S’pore) Accepted version 2019-05-21T07:37:50Z 2019-12-06T16:17:51Z 2019-05-21T07:37:50Z 2019-12-06T16:17:51Z 2018 Journal Article Jiao, Z., Lim, L. H., Hirao, H., & Zhou, S. J. (2018). Palladium-catalyzed para-selective alkylation of electron-deficient arenes. Angewandte Chemie International Edition, 57(21), 6294-6298. doi:10.1002/anie.201801967 1433-7851 https://hdl.handle.net/10356/86198 http://hdl.handle.net/10220/48297 10.1002/anie.201801967 en Angewandte Chemie International Edition © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Jiao, Z., Lim, L. H., Hirao, H., & Zhou, S. J. (2018). Palladium-catalyzed para-selective alkylation of electron-deficient arenes. Angewandte Chemie International Edition, 57(21), 6294-6298, which has been published in final form at http://dx.doi.org/10.1002/anie.201801967. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. 6 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Chemistry
Alkyl Radicals
Alkylation
spellingShingle DRNTU::Science::Chemistry
Alkyl Radicals
Alkylation
Jiao, Zhiwei
Lim, Li Hui
Hirao, Hajime
Zhou, Steve Jianrong
Palladium-catalyzed para-selective alkylation of electron-deficient arenes
description Intermolecular alkylations of electron‐deficient arenes proceed with good para selectivity. Palladium catalysts were used to generate nucleophilic alkyl radicals from alkyl halides, which then directly add onto the arenes. The arene scope and the site of alkylation are opposite to those of classical Friedel–Crafts alkylations, which prefer electron‐rich systems.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Jiao, Zhiwei
Lim, Li Hui
Hirao, Hajime
Zhou, Steve Jianrong
format Article
author Jiao, Zhiwei
Lim, Li Hui
Hirao, Hajime
Zhou, Steve Jianrong
author_sort Jiao, Zhiwei
title Palladium-catalyzed para-selective alkylation of electron-deficient arenes
title_short Palladium-catalyzed para-selective alkylation of electron-deficient arenes
title_full Palladium-catalyzed para-selective alkylation of electron-deficient arenes
title_fullStr Palladium-catalyzed para-selective alkylation of electron-deficient arenes
title_full_unstemmed Palladium-catalyzed para-selective alkylation of electron-deficient arenes
title_sort palladium-catalyzed para-selective alkylation of electron-deficient arenes
publishDate 2019
url https://hdl.handle.net/10356/86198
http://hdl.handle.net/10220/48297
_version_ 1759854251150934016

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