Proteolytic signatures define unique thrombin-derived peptides present in human wound fluid in vivo

• Main Authors: Saravanan, Rathi, Adav, Sunil Shankar, Choong, Yeu Khai, van der Plas, Mariena J. A., Petrlova, Jitka, Kjellström, Sven, Sze, Siu Kwan, Schmidtchen, Artur
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Peptides; Proteases
• Online Access: https://hdl.handle.net/10356/86498; http://hdl.handle.net/10220/44086
• Institution: Nanyang Technological University

The disease burden of failing skin repair and non-healing ulcers is extensive. There is an unmet need for new diagnostic approaches to better predict healing activity and wound infection. Uncontrolled and excessive protease activity, of endogenous or bacterial origin, has been described as a major c...