Optical inhibition of larval zebrafish behaviour with anion channelrhodopsins

Optical inhibition of larval zebrafish behaviour with anion channelrhodopsins

Optical silencing of activity provides a way to test the necessity of neurons in behaviour. Two light-gated anion channels, GtACR1 and GtACR2, have recently been shown to potently inhibit activity in cultured mammalian neurons and in Drosophila. Here, we test the usefulness of these channels in larv...

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Bibliographic Details
Main Authors: Claridge-Chang, Adam, Jesuthasan, Suresh, Mohamed, Gadisti Aisha, Cheng, Ruey-Kuang, Ho, Joses, Krishnan, Seetha, Mohammad, Farhan
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2017
Subjects:
Optogenetics
Zebrafish
Online Access:https://hdl.handle.net/10356/86661
http://hdl.handle.net/10220/44172
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Institution: Nanyang Technological University
Language: English
Description
Summary:Optical silencing of activity provides a way to test the necessity of neurons in behaviour. Two light-gated anion channels, GtACR1 and GtACR2, have recently been shown to potently inhibit activity in cultured mammalian neurons and in Drosophila. Here, we test the usefulness of these channels in larval zebrafish, using spontaneous coiling behaviour as the assay.

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