Optical inhibition of larval zebrafish behaviour with anion channelrhodopsins

• Main Authors: Claridge-Chang, Adam, Jesuthasan, Suresh, Mohamed, Gadisti Aisha, Cheng, Ruey-Kuang, Ho, Joses, Krishnan, Seetha, Mohammad, Farhan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Optogenetics; Zebrafish
• Online Access: https://hdl.handle.net/10356/86661; http://hdl.handle.net/10220/44172
• Institution: Nanyang Technological University

Optical silencing of activity provides a way to test the necessity of neurons in behaviour. Two light-gated anion channels, GtACR1 and GtACR2, have recently been shown to potently inhibit activity in cultured mammalian neurons and in Drosophila. Here, we test the usefulness of these channels in larv...