Optical inhibition of larval zebrafish behaviour with anion channelrhodopsins

• المؤلفون الرئيسيون: Claridge-Chang, Adam, Jesuthasan, Suresh, Mohamed, Gadisti Aisha, Cheng, Ruey-Kuang, Ho, Joses, Krishnan, Seetha, Mohammad, Farhan
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2017
• الموضوعات: Optogenetics; Zebrafish
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/86661; http://hdl.handle.net/10220/44172
• المؤسسة: Nanyang Technological University

Optical silencing of activity provides a way to test the necessity of neurons in behaviour. Two light-gated anion channels, GtACR1 and GtACR2, have recently been shown to potently inhibit activity in cultured mammalian neurons and in Drosophila. Here, we test the usefulness of these channels in larv...