The protein kinase CK2 catalytic domain from Plasmodium falciparum : crystal structure, tyrosine kinase activity and inhibition

• Main Authors: Ruiz-Carrillo, David, Lin, Jianqing, El Sahili, Abbas, Wei, Meng, Sze, Siu Kwan, Doerig, Christian, Lescar, Julien, Cheung, Peter Ching For
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Protein Kinase CK2; Malaria
• Online Access: https://hdl.handle.net/10356/86831; http://hdl.handle.net/10220/45318
• Institution: Nanyang Technological University

Malaria causes every year over half-a-million deaths. The emergence of parasites resistant to available treatments makes the identification of new targets and their inhibitors an urgent task for the development of novel anti-malaria drugs. Protein kinase CK2 is an evolutionary-conserved eukaryotic s...