Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation

• Main Authors: Chu, Trang T. T., Sinha, Ameya, Malleret, Benoit, Suwanarusk, Rossarin, Park, Jung Eun, Naidu, Renugah, Das, Rupambika, Dutta, Bamaprasad, Ong, Seow Theng, Verma, Navin Kumar, Chan, Jerry K., Nosten, François, Rénia, Laurent, Sze, Siu Kwan, Russell, Bruce, Chandramohanadas, Rajesh
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Red Blood Cells; Reticulocytes
• Online Access: https://hdl.handle.net/10356/87031; http://hdl.handle.net/10220/44297
• Institution: Nanyang Technological University

Erythropoiesis is marked by progressive changes in morphological, biochemical and mechanical properties of erythroid precursors to generate red blood cells (RBC). The earliest enucleated forms derived in this process, known as reticulocytes, are multi-lobular and spherical. As reticulocytes mature,...