Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe falciparum malaria : a randomized, controlled, open-label trial

• Main Authors: Charunwatthana, Prakaykaew, Silamut, Kamolrat, Yeo, Tsin Wen, Lee, Sue J., Mukaka, Mavuto, Maude, Richard J., Plewes, Katherine, Md. Mahtab Uddin Hassan, Selim Md. Jahangir, Anstey, Nicholas M., Md. Abul Faiz, Tarning, Joel, Oates, John A., Kingston, Hugh W. F., Ghose, Aniruddha, Wattanakul, Thanaporn, Md. Shafiul Haider, Dutta, Prodip K., Md. Akhterul Islam, Shamsul Alam, Zahed, A. S. M., Md. Abdus Sattar, Chowdhury, M. A. Hassan, Herdman, M. Trent, Leopold, Haruhiko, Piera, Kim A, White, Nicholas J., Md. Amir Hossain, Roberts II, L. Jackson, Dondorp, Arjen M., Turner, Gareth D. H., Day, Nicholas P. J.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: Science::Medicine; Falciparum Malaria; Acute Kidney Injury
• Online Access: https://hdl.handle.net/10356/87102; http://hdl.handle.net/10220/49871
• Institution: Nanyang Technological University

Background: Acute kidney injury independently predicts mortality in falciparum malaria. It is unknown whether acetaminophen’s capacity to inhibit plasma hemoglobin-mediated oxidation is renoprotective in severe malaria. Methods: This phase 2, open-label, randomized controlled trial conducted at two...