Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria

• Main Authors: Kingston, Hugh W. F., Ghose, Aniruddha, Rungpradubvong, Voravut, Satitthummanid, Sudarat, Herdman, M. Trent, Plewes, Katherine, Ishioka, Haruhiko, Leopold, Stije J., Sinha, Ipsita, Intharabut, Benjamas, Piera, Kim, McNeil, Yvette, Mohanty, Sanjib, Maude, Richard J., White, Nicholas J., Day, Nicholas P. J., Yeo, Tsin Wen, Md Amir Hossain, Anstey, Nicholas M., Dondorp, Arjen M.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Severe Malaria; Hemodynamics
• Online Access: https://hdl.handle.net/10356/152850
• Institution: Nanyang Technological University

In severe falciparum malaria, unlike sepsis, hypotension on admission is uncommon. We hypothesized that low nitric oxide bioavailability due to the presence of cell-free hemoglobin (CFH) increases vascular tone in severe malaria.