Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria

• Main Authors: Kingston, Hugh W. F., Ghose, Aniruddha, Rungpradubvong, Voravut, Satitthummanid, Sudarat, Herdman, M. Trent, Plewes, Katherine, Ishioka, Haruhiko, Leopold, Stije J., Sinha, Ipsita, Intharabut, Benjamas, Piera, Kim, McNeil, Yvette, Mohanty, Sanjib, Maude, Richard J., White, Nicholas J., Day, Nicholas P. J., Yeo, Tsin Wen, Md Amir Hossain, Anstey, Nicholas M., Dondorp, Arjen M.
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science::Medicine; Severe Malaria; Hemodynamics
• 在線閱讀: https://hdl.handle.net/10356/152850
• 機構: Nanyang Technological University

In severe falciparum malaria, unlike sepsis, hypotension on admission is uncommon. We hypothesized that low nitric oxide bioavailability due to the presence of cell-free hemoglobin (CFH) increases vascular tone in severe malaria.