Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria
In severe falciparum malaria, unlike sepsis, hypotension on admission is uncommon. We hypothesized that low nitric oxide bioavailability due to the presence of cell-free hemoglobin (CFH) increases vascular tone in severe malaria.
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sg-ntu-dr.10356-1528502023-03-05T16:49:00Z Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria Kingston, Hugh W. F. Ghose, Aniruddha Rungpradubvong, Voravut Satitthummanid, Sudarat Herdman, M. Trent Plewes, Katherine Ishioka, Haruhiko Leopold, Stije J. Sinha, Ipsita Intharabut, Benjamas Piera, Kim McNeil, Yvette Mohanty, Sanjib Maude, Richard J. White, Nicholas J. Day, Nicholas P. J. Yeo, Tsin Wen Md Amir Hossain Anstey, Nicholas M. Dondorp, Arjen M. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Severe Malaria Hemodynamics In severe falciparum malaria, unlike sepsis, hypotension on admission is uncommon. We hypothesized that low nitric oxide bioavailability due to the presence of cell-free hemoglobin (CFH) increases vascular tone in severe malaria. Published version . This work was supported by the Australian National Health and Medical Research Council (grants 605807, 496600, and 1037304 and fellowships 1042072 [to N. M. A.] and 605831 [to T. W. Y.]); the Australian government (UPRS and PIRTS scholarship to H. W. K.); University College, Oxford (Radcliffe Travelling Fellowship to MTH); and the Wellcome Trust, as part of the Wellcome Thailand Trust Major Oversees Programme funding 2021-10-08T07:17:15Z 2021-10-08T07:17:15Z 2020 Journal Article Kingston, H. W. F., Ghose, A., Rungpradubvong, V., Satitthummanid, S., Herdman, M. T., Plewes, K., Ishioka, H., Leopold, S. J., Sinha, I., Intharabut, B., Piera, K., McNeil, Y., Mohanty, S., Maude, R. J., White, N. J., Day, N. P. J., Yeo, T. W., Md Amir Hossain, Anstey, N. M. & Dondorp, A. M. (2020). Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria. Journal of Infectious Diseases, 221(1), 127-137. https://dx.doi.org/10.1093/infdis/jiz359 0022-1899 https://hdl.handle.net/10356/152850 10.1093/infdis/jiz359 31693729 2-s2.0-85076505939 1 221 127 137 en Journal of Infectious Diseases © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf |
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Science::Medicine Severe Malaria Hemodynamics |
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Science::Medicine Severe Malaria Hemodynamics Kingston, Hugh W. F. Ghose, Aniruddha Rungpradubvong, Voravut Satitthummanid, Sudarat Herdman, M. Trent Plewes, Katherine Ishioka, Haruhiko Leopold, Stije J. Sinha, Ipsita Intharabut, Benjamas Piera, Kim McNeil, Yvette Mohanty, Sanjib Maude, Richard J. White, Nicholas J. Day, Nicholas P. J. Yeo, Tsin Wen Md Amir Hossain Anstey, Nicholas M. Dondorp, Arjen M. Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria |
| description |
In severe falciparum malaria, unlike sepsis, hypotension on admission is uncommon. We hypothesized that low nitric oxide bioavailability due to the presence of cell-free hemoglobin (CFH) increases vascular tone in severe malaria. |
| author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Kingston, Hugh W. F. Ghose, Aniruddha Rungpradubvong, Voravut Satitthummanid, Sudarat Herdman, M. Trent Plewes, Katherine Ishioka, Haruhiko Leopold, Stije J. Sinha, Ipsita Intharabut, Benjamas Piera, Kim McNeil, Yvette Mohanty, Sanjib Maude, Richard J. White, Nicholas J. Day, Nicholas P. J. Yeo, Tsin Wen Md Amir Hossain Anstey, Nicholas M. Dondorp, Arjen M. |
| format |
Article |
| author |
Kingston, Hugh W. F. Ghose, Aniruddha Rungpradubvong, Voravut Satitthummanid, Sudarat Herdman, M. Trent Plewes, Katherine Ishioka, Haruhiko Leopold, Stije J. Sinha, Ipsita Intharabut, Benjamas Piera, Kim McNeil, Yvette Mohanty, Sanjib Maude, Richard J. White, Nicholas J. Day, Nicholas P. J. Yeo, Tsin Wen Md Amir Hossain Anstey, Nicholas M. Dondorp, Arjen M. |
| author_sort |
Kingston, Hugh W. F. |
| title |
Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria |
| title_short |
Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria |
| title_full |
Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria |
| title_fullStr |
Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria |
| title_full_unstemmed |
Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria |
| title_sort |
cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria |
| publishDate |
2021 |
| url |
https://hdl.handle.net/10356/152850 |
| _version_ |
1759855872291373056 |