Cell-free hemoglobin is associated with increased vascular resistance and reduced peripheral perfusion in severe malaria

• المؤلفون الرئيسيون: Kingston, Hugh W. F., Ghose, Aniruddha, Rungpradubvong, Voravut, Satitthummanid, Sudarat, Herdman, M. Trent, Plewes, Katherine, Ishioka, Haruhiko, Leopold, Stije J., Sinha, Ipsita, Intharabut, Benjamas, Piera, Kim, McNeil, Yvette, Mohanty, Sanjib, Maude, Richard J., White, Nicholas J., Day, Nicholas P. J., Yeo, Tsin Wen, Md Amir Hossain, Anstey, Nicholas M., Dondorp, Arjen M.
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Medicine; Severe Malaria; Hemodynamics
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/152850

In severe falciparum malaria, unlike sepsis, hypotension on admission is uncommon. We hypothesized that low nitric oxide bioavailability due to the presence of cell-free hemoglobin (CFH) increases vascular tone in severe malaria.