Structure mapping of dengue and Zika viruses reveals functional long-range interactions

• Main Authors: Huber, Roland G., Lim, Xin Ni, Ng, Wy Ching, Sim, Adelene Y. L., Poh, Hui Xian, Shen, Yang, Lim, Su Ying, Sundstrom, Karin B., Sun, Xuyang, Aw, Jong Ghut, Too, Horng Khit, Boey, Peng Hee, Wilm, Andreas, Chawla, Tanu, Choy, Milly M., Jiang, Lu, de Sessions, Paola Florez, Loh, Xian Jun, Alonso, Sylvie, Hibberd, Martin, Nagarajan, Niranjan, Ooi, Eng Eong, Bond, Peter J., Sessions, October M., Wan, Yue
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Zika Virus; Science::Biological sciences; Dengue Virus
• Online Access: https://hdl.handle.net/10356/87105; http://hdl.handle.net/10220/49868
• Institution: Nanyang Technological University

Dengue (DENV) and Zika (ZIKV) viruses are clinically important members of the Flaviviridae family with an 11 kb positive strand RNA genome that folds to enable virus function. Here, we perform structure and interaction mapping on four DENV and ZIKV strains inside virions and in infected cells. Compa...