In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy

In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy

As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa. Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engin...

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Main Authors: Roizman, Dan, Vidaillac, Celine, Givskov, Michael, Yang, Liang
Other Authors: Interdisciplinary Graduate School (IGS)
Format: Article
Language:English
Published: 2018
Subjects:
Antibiotic Resistance
Biofilms
Online Access:https://hdl.handle.net/10356/87235
http://hdl.handle.net/10220/44364
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-872352020-09-21T11:34:53Z In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy Roizman, Dan Vidaillac, Celine Givskov, Michael Yang, Liang Interdisciplinary Graduate School (IGS) School of Biological Sciences Singapore Centre for Environmental Life Sciences Engineering Antibiotic Resistance Biofilms As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa. Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engineered strain PAO1/pBAD-yhjH resulted in increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the use of biofilm dispersal to enhance antimicrobial efficacy in the treatment of biofilm-associated infections, representing a promising therapeutic strategy. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Published version 2018-02-01T04:36:14Z 2019-12-06T16:37:50Z 2018-02-01T04:36:14Z 2019-12-06T16:37:50Z 2017 Journal Article Roizman, D., Vidaillac, C., Givskov, M., & Yang, L. (2017). In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy. Antimicrobial Agents and Chemotherapy, 61(10), e01088-17-. 0066-4804 https://hdl.handle.net/10356/87235 http://hdl.handle.net/10220/44364 10.1128/AAC.01088-17 en Antimicrobial Agents and Chemotherapy © 2017 American Society for Microbiology (ASM). This paper was published in Antimicrobial Agents and Chemotherapy and is made available as an electronic reprint (preprint) with permission of American Society for Microbiology (ASM). The published version is available at: [http://dx.doi.org/10.1128/AAC.01088-17environ]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 5 p. application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Antibiotic Resistance
Biofilms
spellingShingle Antibiotic Resistance
Biofilms
Roizman, Dan
Vidaillac, Celine
Givskov, Michael
Yang, Liang
In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy
description As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa. Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engineered strain PAO1/pBAD-yhjH resulted in increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the use of biofilm dispersal to enhance antimicrobial efficacy in the treatment of biofilm-associated infections, representing a promising therapeutic strategy.
author2 Interdisciplinary Graduate School (IGS)
author_facet Interdisciplinary Graduate School (IGS)
Roizman, Dan
Vidaillac, Celine
Givskov, Michael
Yang, Liang
format Article
author Roizman, Dan
Vidaillac, Celine
Givskov, Michael
Yang, Liang
author_sort Roizman, Dan
title In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy
title_short In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy
title_full In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy
title_fullStr In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy
title_full_unstemmed In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy
title_sort in vitro evaluation of biofilm dispersal as a therapeutic strategy to restore antimicrobial efficacy
publishDate 2018
url https://hdl.handle.net/10356/87235
http://hdl.handle.net/10220/44364
_version_ 1681058517414313984

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