In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy

• Main Authors: Roizman, Dan, Vidaillac, Celine, Givskov, Michael, Yang, Liang
• Other Authors: Interdisciplinary Graduate School (IGS)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Antibiotic Resistance; Biofilms
• Online Access: https://hdl.handle.net/10356/87235; http://hdl.handle.net/10220/44364
• Institution: Nanyang Technological University

As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa. Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engin...