In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy

• المؤلفون الرئيسيون: Roizman, Dan, Vidaillac, Celine, Givskov, Michael, Yang, Liang
• مؤلفون آخرون: Interdisciplinary Graduate School (IGS)
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: Antibiotic Resistance; Biofilms
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/87235; http://hdl.handle.net/10220/44364

As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa. Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engin...