Combination therapy strategy of quorum quenching enzyme and quorum sensing inhibitor in suppressing multiple quorum sensing pathways of P. Aeruginosa

• Main Authors: Fong, July, Zhang, Chaodong, Yang, Renliang, Boo, Zhao Zhi, Tan, Soon Keat, Givskov, Michael, Liu, Xue-Wei, Bin, Wu, Su, Haibin, Yang, Liang, Nielsen, Thomas Eiland
• Other Authors: School of Civil and Environmental Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Quorum Sensing Inhibitors (QSI); Quorum Quenching Enzymes (QQE)
• Online Access: https://hdl.handle.net/10356/87495; http://hdl.handle.net/10220/45422
• Institution: Nanyang Technological University

The threat of antibiotic resistant bacteria has called for alternative antimicrobial strategies that would mitigate the increase of classical resistance mechanism. Many bacteria employ quorum sensing (QS) to govern the production of virulence factors and formation of drug-resistant biofilms. Targeti...