Systematic evaluation of CRISPR-Cas systems reveals design principles for genome editing in human cells

• المؤلفون الرئيسيون: Wang, Yuanming, Liu, Ivy Kaiwen, Sutrisnoh, Norfala-Aliah, Srinivasan, Harini, Zhang, Junyi, Li, Jia, Zhang, Fan, Lalith, Charles Richard John, Xing, Heyun, Shanmugam, Raghuvaran, Foo, Jia Nee, Yeo, Hwee Ting, Ooi, Kean Hean, Bleckwehl, Tore, Par, Rachel Yi Yun, Lee, Shi Mun, Ismail, Nur Nadiah, Sanwari, Nur Aidah, Lee, Vanessa Si Ting, Lew, Jan, Tan, Meng How
• مؤلفون آخرون: School of Chemical and Biomedical Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: CRISPR; Genome Editing
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/87501; http://hdl.handle.net/10220/45417

Background: While CRISPR-Cas systems hold tremendous potential for engineering the human genome, it is unclear how well each system performs against one another in both non-homologous end joining (NHEJ)-mediated and homology-directed repair (HDR)-mediated genome editing. Results: We systematically c...