Development of a multi-compartment population balance model for high-shear wet granulation with discrete element method

• Main Authors: Lee, Kok Foong, Dosta, Maksym, McGuire, Andrew D., Mosbach, Sebastian, Wagner, Wolfgang, Heinrich, Stefan, Kraft, Markus
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Stochastic Weighted Algorithm; Granulation
• Online Access: https://hdl.handle.net/10356/88020; http://hdl.handle.net/10220/44503
• Institution: Nanyang Technological University

This paper presents a multi-compartment population balance model for wet granulation coupled with DEM (discrete element method) simulations. Methodologies are developed to extract relevant data from the DEM simulations to inform the population balance model. First, compartmental residence times are...