Oncofetal HMGA2 effectively curbs unconstrained (+) and (−) DNA supercoiling
HMGA2 belongs to the family of the high mobility group (HMG) proteins. It binds DNA via three AT-hook domains to the minor groove of adenine-thymine (AT) rich DNA. Recently, a new function of HMGA2 as a replication fork chaperone that protects stem and cancer cells from replication fork collapse ind...
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| Main Authors: | , , , |
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| 格式: | Article |
| 語言: | English |
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2018
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| 在線閱讀: | https://hdl.handle.net/10356/88125 http://hdl.handle.net/10220/45636 |
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