Novel application of in vivo micro-optical coherence tomography to assess cornea scarring in an animal model

• Main Authors: Ang, Marcus, Devarajan, Kavya, Das, Suchandrima, Yam, Gary H. F., Htoon, Hla Mynt, Chen, Si, Liu, Xinyu, Liu, Linbo, Girard, Michael, Mehta, Jodhbir S.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Cornea Scarring; DRNTU::Engineering::Electrical and electronic engineering; Micro-Optical Coherence Tomography (micro-OCT)
• Online Access: https://hdl.handle.net/10356/88160; http://hdl.handle.net/10220/45657
• Institution: Nanyang Technological University

This pilot study uses a micro-optical coherence tomography (micro-OCT) system with ~1 μm axial resolution specifically to image the cornea and corneal scars in vivo. We used an established murine corneal scar model by irregular phototherapeutic keratectomy in ten C57BL/6 mice, with serial imaging us...