Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches

• Main Authors: Kaan, Hung Yi Kristal, Sim, Adelene Y. L., Tan, Siew Kim Joyce, Verma, Chandra, Song, Haiwei
• Other Authors: Ye, Sheng
• Format: Article
• Language: English
• Published: 2018
• Subjects: Phenylalanine; Transcription Factor TAZ
• Online Access: https://hdl.handle.net/10356/88193; http://hdl.handle.net/10220/44583
• Institution: Nanyang Technological University

The Hippo signaling pathway, which is implicated in the regulation of organ size, has emerged as a potential target for the development of cancer therapeutics. YAP, TAZ (transcription co-activators) and TEAD (transcription factor) are the downstream transcriptional machinery and effectors of the pat...