Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches

• المؤلفون الرئيسيون: Kaan, Hung Yi Kristal, Sim, Adelene Y. L., Tan, Siew Kim Joyce, Verma, Chandra, Song, Haiwei
• مؤلفون آخرون: Ye, Sheng
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: Phenylalanine; Transcription Factor TAZ
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/88193; http://hdl.handle.net/10220/44583

The Hippo signaling pathway, which is implicated in the regulation of organ size, has emerged as a potential target for the development of cancer therapeutics. YAP, TAZ (transcription co-activators) and TEAD (transcription factor) are the downstream transcriptional machinery and effectors of the pat...