Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches

• Main Authors: Kaan, Hung Yi Kristal, Sim, Adelene Y. L., Tan, Siew Kim Joyce, Verma, Chandra, Song, Haiwei
• 其他作者: Ye, Sheng
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Phenylalanine; Transcription Factor TAZ
• 在線閱讀: https://hdl.handle.net/10356/88193; http://hdl.handle.net/10220/44583
• 機構: Nanyang Technological University

The Hippo signaling pathway, which is implicated in the regulation of organ size, has emerged as a potential target for the development of cancer therapeutics. YAP, TAZ (transcription co-activators) and TEAD (transcription factor) are the downstream transcriptional machinery and effectors of the pat...