A Biodegradable, Sustained-Released, Tacrolimus Microfilm Drug Delivery System for the Management of Allergic Conjunctivitis in a Mouse Model

• Main Authors: Liu, Yu-Chi, Ng, Xu Wen, Teo, Ericia Pei Wen, Ang, Heng-Pei, Lwin, Nyein Chan, Chan, Nicole Shu Wen, Venkatraman, Subbu S., Wong, Tina Tzeeling, Mehta, Jodhbir Singh
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Allergic Conjunctivitis; Tacrolimus
• Online Access: https://hdl.handle.net/10356/88206; http://hdl.handle.net/10220/44577
• Institution: Nanyang Technological University

Purpose: To investigate the drug release profiles of a tacrolimus-loaded poly(D,L-lactide-co-ε-caprolactone) (PLC) microfilm, and to evaluate its efficacy on the treatment of allergic conjunctivitis using a mouse model. Methods: The in vitro and in vivo drug release profiles were first characteri...