Cell-based high-throughput compound screening reveals functional interaction between oncofetal HMGA2 and topoisomerase I

• Main Authors: Peter, Sabrina, Yu, Haojie, Ivanyi-Nagy, Roland, Dröge, Peter
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Topoisomerase; DRNTU::Science::Biological sciences; HMGA2
• Online Access: https://hdl.handle.net/10356/88392; http://hdl.handle.net/10220/45779
• Institution: Nanyang Technological University

HMGA2 is an important chromatin factor that interacts with DNA via three AT-hook domains, thereby regulating chromatin architecture and transcription during embryonic and fetal development. The protein is absent from differentiated somatic cells, but aberrantly re-expressed in most aggressive human...