G-quadruplexes with (4n - 1) guanines in the G-tetrad core : formation of a G-triad·water complex and implication for small-molecule binding

• Main Authors: Heddi, Brahim, Martín-Pintado, Nerea, Serimbetov, Zhalgas, Teuku Mahfuzh Aufar Kari, Phan, Anh Tuan
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Chemistry; G-quadruplexes; G-triad
• Online Access: https://hdl.handle.net/10356/88403; http://hdl.handle.net/10220/45778
• Institution: Nanyang Technological University

G-quadruplexes are non-canonical structures of nucleic acids, in which guanine bases form planar G-tetrads (G·G·G·G) that stack on each other in the core of the structure. G-quadruplexes generally contain multiple times of four (4n) guanines in the core. Here, we study the structure of G-quadruplexe...