The Drosophila Dicer-1 partner loquacious enhances miRNA processing from hairpins with unstable structures at the dicing site

• Main Authors: Lim, Mandy Yu Theng, Ng, Alvin Wei Tian, Chou, Yuting, Lim, Teck Por, Simcox, Amanda, Tucker-Kellogg, Greg, Okamura, Katsutomo
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Drosophila Proteins; RNA Processing; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/88607; http://hdl.handle.net/10220/46946
• Institution: Nanyang Technological University

In Drosophila, Dicer-1 binds Loquacious-PB (Loqs-PB) as its major co-factor. Previous analyses indicated that loqs mutants only partially impede miRNA processing, but the activity of minor isoforms or maternally deposited Loqs was not eliminated in these studies. We addressed this by generating a ce...