Oxidative phosphorylation as a target space for tuberculosis: success, caution, and future directions

• Main Authors: Cook, Gregory M., Hards, Kiel, Dunn, Elyse, Heikal, Adam, Nakatani, Yoshio, Greening, Chris, Crick, Dean C., Fontes, Fabio L., Pethe, Kevin, Hasenoehrl, Erik, Berney, Michael
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Oxidoreductase; Tuberculostatic Agent; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/88834; http://hdl.handle.net/10220/45962
• Institution: Nanyang Technological University

The emergence and spread of drug-resistant pathogens, and our inability to develop new antimicrobials to combat resistance, have inspired scientists to seek out new targets for drug development. The Mycobacterium tuberculosis complex is a group of obligately aerobic bacteria that have specialized fo...