The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

• المؤلفون الرئيسيون: Zhu, Lei, Tripathi, Jaishree, Rocamora, Frances Maureen, Miotto, Olivo, van der Pluijm, Rob, Voss, Till S., Mok, Sachel, Kwiatkowski, Dominic P., Nosten, François, Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M., Bozdech, Zbynek
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Plasmodium Falciparum; DRNTU::Science::Biological sciences; Greater Mekong Subregion
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/89113; http://hdl.handle.net/10220/47669

The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain of casualty underlying artemisinin resistance, we reanalyze 773 P. falciparum isolates from TRACI-st...