The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

• Main Authors: Zhu, Lei, Tripathi, Jaishree, Rocamora, Frances Maureen, Miotto, Olivo, van der Pluijm, Rob, Voss, Till S., Mok, Sachel, Kwiatkowski, Dominic P., Nosten, François, Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M., Bozdech, Zbynek
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Plasmodium Falciparum; DRNTU::Science::Biological sciences; Greater Mekong Subregion
• Online Access: https://hdl.handle.net/10356/89113; http://hdl.handle.net/10220/47669
• Institution: Nanyang Technological University

The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain of casualty underlying artemisinin resistance, we reanalyze 773 P. falciparum isolates from TRACI-st...