Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification

• Main Authors: Pathak, Anuj, Bergstrand, Jan, Sender, Vicky, Spelmink, Laura, Aschtgen, Marie-Stephanie, Muschiol, Sandra, Widengren, Jerker, Henriques-Normark, Birgitta
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: C3b Deposition; DRNTU::Science::Medicine; Binding Proteins
• Online Access: https://hdl.handle.net/10356/89123; http://hdl.handle.net/10220/46073
• Institution: Nanyang Technological University

Streptococcus pneumoniae evades C3-mediated opsonization and effector functions by expressing an immuno-protective polysaccharide capsule and Factor H (FH)-binding proteins. Here we use super-resolution microscopy, mutants and functional analysis to show how these two defense mechanisms are function...