Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial–mesenchymal transition by inducing 14-3-3γ expression

• Main Authors: Teo, Ziqiang, Sng, Ming Keat, Chan, Jeremy Soon Kiat, Lim, Maegan Miang Kee, Li, Yinliang, Li, Luchun, Phua, Terri, Lee, J. Y. H., Tan, Zhen Wei, Zhu, Pengcheng, Tan, Nguan Soon
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Cancer; Cell Biology
• Online Access: https://hdl.handle.net/10356/89157; http://hdl.handle.net/10220/44840
• Institution: Nanyang Technological University

Metastatic cancer cells acquire energy-intensive processes including increased invasiveness and chemoresistance. However, how the energy demand is met and the molecular drivers that coordinate an increase in cellular metabolic activity to drive epithelial–mesenchymal transition (EMT), the first step...