Structural design of microbicidal cationic oligomers and their synergistic interaction with azoles against Candida albicans

• Main Authors: Yuan, Yuan, Zhou, Feng, Su, Haibin, Zhang, Yugen
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Engineering::Materials; Oligomers; Antimicrobial Resistance
• Online Access: https://hdl.handle.net/10356/89198; http://hdl.handle.net/10220/49898
• Institution: Nanyang Technological University

Membrane-disrupting synthetic antimicrobial polymers have been well developed as antimicrobial peptide (AMP) mimics to mitigate antimicrobial resistance (AMR). However, synthetic polymers possess inherent drawbacks, being a mixture of different chain lengths, which restricts their clinical applicati...