A general method for asymmetric arylation and vinylation of silyl ketene acetals
A new biarylmonophosphine was developed for highly asymmetric arylation and vinylation of silyl enolates of acyclic esters with good generality. The new stereocenters α to the ester groups were formed in high enantiomeric excess. The method was applied to the asymmetric synthesis of Profen drugs on...
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sg-ntu-dr.10356-893692023-02-28T19:24:09Z A general method for asymmetric arylation and vinylation of silyl ketene acetals Yang, Junfeng Zhou, Jianrong (Steve) School of Physical and Mathematical Sciences Asymmetric Arylation Vinylation A new biarylmonophosphine was developed for highly asymmetric arylation and vinylation of silyl enolates of acyclic esters with good generality. The new stereocenters α to the ester groups were formed in high enantiomeric excess. The method was applied to the asymmetric synthesis of Profen drugs on a gram scale. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Accepted version 2018-05-24T03:26:53Z 2019-12-06T17:24:00Z 2018-05-24T03:26:53Z 2019-12-06T17:24:00Z 2014 Journal Article Yang, J., & Zhou, J. (S.) (2014). A general method for asymmetric arylation and vinylation of silyl ketene acetals. Organic Chemistry Frontiers, 1(4), 365-367. 2052-4110 https://hdl.handle.net/10356/89369 http://hdl.handle.net/10220/44886 10.1039/C4QO00027G en Organic Chemistry Frontiers © 2014 the Partner Organisations. This is the author created version of a work that has been peer reviewed and accepted for publication by Organic Chemistry Frontiers, the Partner Organisations. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C4QO00027G]. 4 p. application/pdf |
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Asymmetric Arylation Vinylation |
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Asymmetric Arylation Vinylation Yang, Junfeng Zhou, Jianrong (Steve) A general method for asymmetric arylation and vinylation of silyl ketene acetals |
| description |
A new biarylmonophosphine was developed for highly asymmetric arylation and vinylation of silyl enolates of acyclic esters with good generality. The new stereocenters α to the ester groups were formed in high enantiomeric excess. The method was applied to the asymmetric synthesis of Profen drugs on a gram scale. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Yang, Junfeng Zhou, Jianrong (Steve) |
| format |
Article |
| author |
Yang, Junfeng Zhou, Jianrong (Steve) |
| author_sort |
Yang, Junfeng |
| title |
A general method for asymmetric arylation and vinylation of silyl ketene acetals |
| title_short |
A general method for asymmetric arylation and vinylation of silyl ketene acetals |
| title_full |
A general method for asymmetric arylation and vinylation of silyl ketene acetals |
| title_fullStr |
A general method for asymmetric arylation and vinylation of silyl ketene acetals |
| title_full_unstemmed |
A general method for asymmetric arylation and vinylation of silyl ketene acetals |
| title_sort |
general method for asymmetric arylation and vinylation of silyl ketene acetals |
| publishDate |
2018 |
| url |
https://hdl.handle.net/10356/89369 http://hdl.handle.net/10220/44886 |
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1759854163053772800 |