Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

• Main Authors: Davey, Gabriela Elzbieta, Adhireksan, Zenita, Ma, Zhujun, Riedel, Tina, Sharma, Deepti, Padavattan, Sivaraman, Rhodes, Daniela, Ludwig, Alexander, Sandin, Sara, Murray, Benjamin S., Dyson, Paul J., Davey, Curtis Alexander
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Ruthenium; Chromatin Condensation
• Online Access: https://hdl.handle.net/10356/89472; http://hdl.handle.net/10220/44965
• Institution: Nanyang Technological University

The ‘acidic patch’ is a highly electronegative cleft on the histone H2A–H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially therapeutic site with exogenous molecules remains unclear. Here, we charact...