Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant

• Main Authors: Pham, Huong Thi, Nhiep, Nguyen Thi Hanh, Vu, Thu Ngoc Minh, Huynh, TuAnh Ngoc, Zhu, Yan, Huynh, Anh Le Diep, Chakrabortti, Alolika, Marcellin, Esteban, Lo, Raquel, Howard, Christopher B., Bansal, Nidhi, Liang, Zhao-Xun, Turner, Mark S., Woodward, Joshua J.
• Other Authors: Garsin, Danielle A.
• Format: Article
• Language: English
• Published: 2018
• Subjects: Lactococcus Mutant; Osmoresistance; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/89801; http://hdl.handle.net/10220/46391
• Institution: Nanyang Technological University

The broadly conserved bacterial signalling molecule cyclic-di-adenosine monophosphate (c-di-AMP) controls osmoresistance via its regulation of potassium (K+) and compatible solute uptake. High levels of c-di-AMP resulting from inactivation of c-di-AMP phosphodiesterase activity leads to poor growth...