Mapping of γ/δ t cells reveals vδ2+ t cells resistance to senescence

• Main Authors: Xu, Weili, Monaco, Gianni, Wong, Eleanor Huijin, Tan, Wilson Lek Wen, Kared, Hassen, Simoni, Yannick, Tan, Shu Wen, How, Wilson Zhi Yong, Tan, Crystal Tze Ying, Lee, Bernett Teck Kwong, Carbajo, Daniel, K.G., Srinivasan, Low, Ivy Chay Huang, Mok, Esther Wing Hei, Foo, Shihui, Lum, Josephine, Tey, Hong Liang, Tan, Wee Ping, Poidinger, Michael, Newell, Evan, Ng, Tze Pin, Foo, Roger, Akbar, Arne N., Fülöp, Tamas, Larbi, Anis
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Cellular Senescence; Aging; DRNTU::Science::Biological sciences::Microbiology::Immunology
• Online Access: https://hdl.handle.net/10356/89850; http://hdl.handle.net/10220/47744
• Institution: Nanyang Technological University

Background: Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ T cells have been neglected despite their role in immunosurveillance. We investigated the impact of aging on γδ T cell subsets phenotypes, functions, senescence and thei...