Oncogenic activation of the stat3 pathway drives pd-l1 expression in natural killer/t-cell lymphoma

• Main Authors: Song, Tammy Linlin, Nairismägi, Maarja-Liisa, Laurensia, Yurike, Lim, Jing-Quan, Tan, Jing, Li, Zhi-Mei, Pang, Wan-Lu, Kizhakeyil, Atish, Wijaya, Giovani-Claresta, Huang, Da-Chuan, Nagarajan, Sanjanaa, Chia, Burton Kuan-Hui, Cheah, Daryl, Liu, Yan-Hui, Zhang, Fen, Rao, Hui-Lan, Tang, Tiffany, Wong, Esther Kam-Yin, Bei, Jin-Xin, Iqbal, Jabed, Grigoropoulos, Nicholas-Francis, Ng, Siok-Bian, Chng, Wee-Joo, Teh, Bin-Tean, Tan, Soo-Yong, Verma, Navin Kumar, Fan, Hao, Lim, Soon-Thye, Ong, Choon-Kiat
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: Anaplastic Lymphoma Kinase; Ephrin Receptor A3; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/89903; http://hdl.handle.net/10220/47777
• Institution: Nanyang Technological University

Mature T-cell lymphomas, including peripheral T-cell lymphoma (PTCL) and extranodal NK/T-cell lymphoma (NKTL), represent a heterogeneous group of non-Hodgkin lymphomas with dismal outcomes and limited treatment options. To determine the extent of involvement of the JAK/STAT pathway in this malignanc...