Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation

• Main Authors: Vasudevan, Subhash G., Peng, Minhua, Swarbrick, Crystall Marie Dawn, Chan, Kitti Wing-Ki, Luo, Dahai, Zhang, Wei, Lai, Xiaoping, Li, Geng
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Medicine; Dengue Virus; Luteolin
• Online Access: https://hdl.handle.net/10356/90097; http://hdl.handle.net/10220/48386
• Institution: Nanyang Technological University

We previously showed that luteolin, a well-known plant-derived component found in the “heat clearing” class of Traditional Chinese Medicine (TCM) herbs, is an uncompetitive inhibitor (Ki 58.6 μM) of the host proprotein convertase furin, an endoprotease that is required for maturation of flaviviruses...