Scandium as a pre-catalyst for the deoxygenative allylation of benzylic alcohols

Scandium triflate is an effective pre-catalyst for the deoxygenative allylation of benzylic alcohols with a narrow substrate window. The reaction is shown to proceed through a “hidden Brønsted acid” mechanism. The reaction is efficient provided that the aryl group is neither too electron rich nor to...

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Main Authors: Šolić, Ivan, Seankongsuk, Pattarakiat, Loh, Joanna Kejun, Vilaivan, Tirayut, Bates, Roderick Wayland
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2019
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Online Access:https://hdl.handle.net/10356/90299
http://hdl.handle.net/10220/48477
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-902992023-02-28T19:37:07Z Scandium as a pre-catalyst for the deoxygenative allylation of benzylic alcohols Šolić, Ivan Seankongsuk, Pattarakiat Loh, Joanna Kejun Vilaivan, Tirayut Bates, Roderick Wayland School of Physical and Mathematical Sciences DRNTU::Science::Chemistry Allylation Benzylic Alcohols Scandium triflate is an effective pre-catalyst for the deoxygenative allylation of benzylic alcohols with a narrow substrate window. The reaction is shown to proceed through a “hidden Brønsted acid” mechanism. The reaction is efficient provided that the aryl group is neither too electron rich nor too electron poor. It is shown that this allows useful selectivity. The reaction also works for benzyhydryl alcohols with broader scope. The reaction may also be catalysed by Nafion. ASTAR (Agency for Sci., Tech. and Research, S’pore) Accepted version 2019-05-30T02:32:07Z 2019-12-06T17:45:11Z 2019-05-30T02:32:07Z 2019-12-06T17:45:11Z 2017 Journal Article Šolić, I., Seankongsuk, P., Loh, J. K., Vilaivan, T., & Bates, R. W. (2018). Scandium as a pre-catalyst for the deoxygenative allylation of benzylic alcohols. Organic & Biomolecular Chemistry, 16(1), 119-123. doi:10.1039/C7OB02219K 1477-0520 https://hdl.handle.net/10356/90299 http://hdl.handle.net/10220/48477 10.1039/C7OB02219K en Organic & Biomolecular Chemistry © 2018 The Royal Society of Chemistry. All rights reserved. This paper was published in Organic & Biomolecular Chemistry and is made available with permission of The Royal Society of Chemistry. 5 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Chemistry
Allylation
Benzylic Alcohols
spellingShingle DRNTU::Science::Chemistry
Allylation
Benzylic Alcohols
Šolić, Ivan
Seankongsuk, Pattarakiat
Loh, Joanna Kejun
Vilaivan, Tirayut
Bates, Roderick Wayland
Scandium as a pre-catalyst for the deoxygenative allylation of benzylic alcohols
description Scandium triflate is an effective pre-catalyst for the deoxygenative allylation of benzylic alcohols with a narrow substrate window. The reaction is shown to proceed through a “hidden Brønsted acid” mechanism. The reaction is efficient provided that the aryl group is neither too electron rich nor too electron poor. It is shown that this allows useful selectivity. The reaction also works for benzyhydryl alcohols with broader scope. The reaction may also be catalysed by Nafion.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Šolić, Ivan
Seankongsuk, Pattarakiat
Loh, Joanna Kejun
Vilaivan, Tirayut
Bates, Roderick Wayland
format Article
author Šolić, Ivan
Seankongsuk, Pattarakiat
Loh, Joanna Kejun
Vilaivan, Tirayut
Bates, Roderick Wayland
author_sort Šolić, Ivan
title Scandium as a pre-catalyst for the deoxygenative allylation of benzylic alcohols
title_short Scandium as a pre-catalyst for the deoxygenative allylation of benzylic alcohols
title_full Scandium as a pre-catalyst for the deoxygenative allylation of benzylic alcohols
title_fullStr Scandium as a pre-catalyst for the deoxygenative allylation of benzylic alcohols
title_full_unstemmed Scandium as a pre-catalyst for the deoxygenative allylation of benzylic alcohols
title_sort scandium as a pre-catalyst for the deoxygenative allylation of benzylic alcohols
publishDate 2019
url https://hdl.handle.net/10356/90299
http://hdl.handle.net/10220/48477
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