A tail-based mechanism drives nucleosome demethylation by the LSD2/NPAC multimeric complex

A tail-based mechanism drives nucleosome demethylation by the LSD2/NPAC multimeric complex

LSD1 and LSD2 are homologous histone demethylases with opposite biological outcomes related to chromatin silencing and transcription elongation, respectively. Unlike LSD1, LSD2 nucleosome-demethylase activity relies on a specific linker peptide from the multidomain protein NPAC. We used single-parti...

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Bibliographic Details
Main Authors: Marabelli, Chiara, Marrocco, Biagina, Pilotto, Simona, Chittori, Sagar, Picaud, Sarah, Marchese, Sara, Ciossani, Giuseppe, Forneris, Federico, Filippakopoulos, Panagis, Schoehn, Guy, Rhodes, Daniela, Subramaniam, Sriram, Mattevi, Andrea
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2019
Subjects:
Histone Demethylation
Cryoelectron Microscopy
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/93135
http://hdl.handle.net/10220/48524
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/93135
http://hdl.handle.net/10220/48524

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