A tail-based mechanism drives nucleosome demethylation by the LSD2/NPAC multimeric complex
LSD1 and LSD2 are homologous histone demethylases with opposite biological outcomes related to chromatin silencing and transcription elongation, respectively. Unlike LSD1, LSD2 nucleosome-demethylase activity relies on a specific linker peptide from the multidomain protein NPAC. We used single-parti...
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| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/93135 http://hdl.handle.net/10220/48524 |
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| Institution: | Nanyang Technological University |
| Language: | English |